What the FDA labels say about taking them together
Avanafil and sodium nitroprusside
Avanafil's FDA label of December 17, 2025 names sodium nitroprusside in its warnings and precautions section; the sodium nitroprusside labels PlainMeds reads (2) do not name avanafil.
Check it at the source: the avanafil FDA label on DailyMed (effective December 17, 2025, Camber Pharmaceuticals, Inc.); the sodium nitroprusside FDA label on DailyMed (effective August 10, 2026, Micro Labs Limited).
What does the avanafil label say about sodium nitroprusside?
Avanafil label, warnings and precautionsIn vitro studies with human platelets indicate that avanafil potentiates the anti-aggregatory effect of sodium nitroprusside (a nitric oxide [NO] donor).
Source: FDA drug label (Avanafil), ANDA209266 (Hetero Labs Ltd V), as published by Camber Pharmaceuticals, Inc., effective December 17, 2025 (SPL set 1d04e17d-7399-430a-a8bb-fa1912b155e9), via openFDA; the full label on DailyMed
What does the sodium nitroprusside label say about avanafil?
Sodium nitroprusside's label (effective August 10, 2026) and its 1 other brand-application label do not name avanafil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SODIUM NITROPRUSSIDE), Micro Labs Limited, effective August 10, 2026 (SPL set 5a599880-c133-44ef-a9f2-bd1b681563be), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Avanafil | Sodium nitroprusside | |
|---|---|---|
| Labeled for | Erectile dysfunction | Heart failure |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $50.00 per tablet 200 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once