What the FDA labels say about taking them together
Avanafil and nitroglycerin
Nitroglycerin's FDA label of February 15, 2023 names avanafil in its contraindications section; avanafil's label does not name nitroglycerin itself but warns about its class (nitrate vasodilators).
Check it at the source: the avanafil FDA label on DailyMed (effective December 17, 2025, Camber Pharmaceuticals, Inc.); the nitroglycerin FDA label on DailyMed (effective February 15, 2023, Viatris Specialty LLC).
What does the avanafil label say about nitroglycerin?
Avanafil's label does not name nitroglycerin itself; it warns about its class (nitrate vasodilators):
Avanafil label, contraindicationsAdministration of avanafil tablet to patients using any form of organic nitrate is contraindicated
Avanafil label, contraindicationsAdministration of avanafil tablets with any form of organic nitrates, either regularly and/or intermittently, is contraindicated.
Source: FDA drug label (Avanafil), ANDA209266 (Hetero Labs Ltd V), as published by Camber Pharmaceuticals, Inc., effective December 17, 2025 (SPL set 1d04e17d-7399-430a-a8bb-fa1912b155e9), via openFDA; the full label on DailyMed
What does the nitroglycerin label say about avanafil?
Nitroglycerin label, contraindicationsUse of phosphodiesterase type 5 (PDE-5) inhibitors, such as avanafil, sildenafil, tadalafil, or vardenafil, or soluble guanylate cyclase (sGC) stimulators.
Nitroglycerin label, drug interactionsPDE-5-Inhibitors such as avanafil, sildenafil, vardenafil, and tadalafil have been shown to potentiate the hypotensive effects of organic nitrates.
Source: FDA drug label (Nitrostat), Viatris Specialty LLC, effective February 15, 2023 (SPL set 9a52da75-d0af-4237-96c0-0b12adfa8636), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Avanafil | Nitroglycerin | |
|---|---|---|
| Labeled for | Erectile dysfunction | Angina, High blood pressure, Heart failure, Heart attack and coronary artery disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $50.00 per tablet 200 mg tablet | $0.127 per tablet 0.4 mg tablet sl |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once