What the FDA labels say about taking them together
Avanafil and ketoconazole
Avanafil's FDA label of December 17, 2025 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name avanafil. The avanafil label: “CYP3A4 inhibitors increase avanafil exposure”
Check it at the source: the avanafil FDA label on DailyMed (effective December 17, 2025, Camber Pharmaceuticals, Inc.); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the avanafil label say about ketoconazole?
Avanafil label, drug interactionsCYP3A4 inhibitors (e.g., ketoconazole, ritonavir, erythromycin) increase avanafil exposure
Avanafil label, warnings and precautionsFor patients taking concomitant strong CYP3A4 inhibitors (including ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir and telithromycin), do not use avanafil [see Drug Interactions ( 7.2 )].
Source: FDA drug label (Avanafil), ANDA209266 (Hetero Labs Ltd V), as published by Camber Pharmaceuticals, Inc., effective December 17, 2025 (SPL set 1d04e17d-7399-430a-a8bb-fa1912b155e9), via openFDA; the full label on DailyMed
What does the ketoconazole label say about avanafil?
Ketoconazole's label (effective January 28, 2026) does not name avanafil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Avanafil | Ketoconazole | |
|---|---|---|
| Labeled for | Erectile dysfunction | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $50.00 per tablet 200 mg tablet | $0.249 per gram 2% cream |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once