What the FDA labels say about taking them together
Avanafil and erythromycin
Avanafil's FDA label of December 17, 2025 names erythromycin in its drug interactions section; the erythromycin labels PlainMeds reads (4) do not name avanafil. The avanafil label: “CYP3A4 inhibitors increase avanafil exposure”
Check it at the source: the avanafil FDA label on DailyMed (effective December 17, 2025, Camber Pharmaceuticals, Inc.); the erythromycin FDA label on DailyMed (effective August 1, 2024, Teva Pharmaceuticals USA, Inc.).
What does the avanafil label say about erythromycin?
Avanafil label, drug interactionsCYP3A4 inhibitors (e.g., ketoconazole, ritonavir, erythromycin) increase avanafil exposure
Avanafil label, warnings and precautionsFor patients taking concomitant moderate CYP3A4 inhibitors (including erythromycin, amprenavir, aprepitant, diltiazem, fluconazole, fosamprenavir, and verapamil), the maximum recommended dose of avanafil is 50 mg, not to exceed once every 24 hours [see Drug Interactions ( 7.2 )].
Source: FDA drug label (Avanafil), ANDA209266 (Hetero Labs Ltd V), as published by Camber Pharmaceuticals, Inc., effective December 17, 2025 (SPL set 1d04e17d-7399-430a-a8bb-fa1912b155e9), via openFDA; the full label on DailyMed
What does the erythromycin label say about avanafil?
Erythromycin's label (effective August 1, 2024) and its 3 other brand-application labels do not name avanafil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Erythromycin), Teva Pharmaceuticals USA, Inc., effective August 1, 2024 (SPL set 75a0bd5a-d09f-483b-bfd8-f8343b149eb2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Avanafil | Erythromycin | |
|---|---|---|
| Labeled for | Erectile dysfunction | Bacterial infections, Acne |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $50.00 per tablet 200 mg tablet | $1.96 per tablet 250 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once