What the FDA labels say about taking them together
Avanafil and darunavir
Darunavir's FDA label of August 29, 2025 names avanafil in its drug interactions section; the avanafil label PlainMeds reads does not name darunavir. The darunavir label: “… inhibitor-associated adverse events. Co-administration of PREZISTA/ritonavir and avanafil is not recommended.”
Check it at the source: the avanafil FDA label on DailyMed (effective December 17, 2025, Camber Pharmaceuticals, Inc.); the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP).
What does the avanafil label say about darunavir?
Avanafil's label (effective December 17, 2025) does not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Avanafil), ANDA209266 (Hetero Labs Ltd V), as published by Camber Pharmaceuticals, Inc., effective December 17, 2025 (SPL set 1d04e17d-7399-430a-a8bb-fa1912b155e9), via openFDA; the full label on DailyMed
What does the darunavir label say about avanafil?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: PDE-5 inhibitors: e.g. avanafil, sildenafil, tadalafil, vardenafil; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ PDE-5 inhibitors (only the use of sildenafil at doses used for treatment of erectile dysfunction has been studied with PREZISTA/ritonavir); Clinical Comment: Co-administration with PREZISTA/ritonavir may result in an increase in PDE-5 inhibitor-associated adverse events, including hypotension, syncope, visual disturbances and priapism. …
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Avanafil | Darunavir | |
|---|---|---|
| Labeled for | Erectile dysfunction | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $50.00 per tablet 200 mg tablet | $1.16 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once