What the FDA labels say about taking them together
Avacopan and simvastatin
Avacopan's FDA label of June 2, 2026 names simvastatin in its drug interactions section; the simvastatin label PlainMeds reads does not name avacopan. The avacopan label: “Co-administration of avacopan and 40 mg simvastatin increases the systemic exposure of simvastatin.”
Check it at the source: the avacopan FDA label on DailyMed (effective June 2, 2026, ChemoCentryx, Inc.); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the avacopan label say about simvastatin?
Avacopan label, drug interactionsCo-administration of avacopan and 40 mg simvastatin increases the systemic exposure of simvastatin.
Source: FDA drug label (TAVNEOS), ChemoCentryx, Inc., effective June 2, 2026 (SPL set c93cbc0b-29a3-46a5-9c85-41815ea5cf4a), via openFDA; the full label on DailyMed
What does the simvastatin label say about avacopan?
Simvastatin's label (effective March 28, 2025) does not name avacopan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Avacopan | Simvastatin | |
|---|---|---|
| Labeled for | n/a | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.0321 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once