What the FDA labels say about taking them together
Avacopan and rifampin
Avacopan's FDA label of June 2, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name avacopan. The avacopan label: “Avacopan exposure is decreased when co-administered with strong CYP3A4 enzyme inducers such as rifampin.”
Check it at the source: the avacopan FDA label on DailyMed (effective June 2, 2026, ChemoCentryx, Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the avacopan label say about rifampin?
Avacopan label, drug interactionsAvacopan exposure is decreased when co-administered with strong CYP3A4 enzyme inducers such as rifampin [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (TAVNEOS), ChemoCentryx, Inc., effective June 2, 2026 (SPL set c93cbc0b-29a3-46a5-9c85-41815ea5cf4a), via openFDA; the full label on DailyMed
What does the rifampin label say about avacopan?
Rifampin's label (effective February 11, 2026) does not name avacopan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Avacopan | Rifampin | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once