What the FDA labels say about taking them together
Avacopan and itraconazole
Avacopan's FDA label of June 2, 2026 names itraconazole in its drug interactions section; the itraconazole labels PlainMeds reads (2) do not name avacopan. The avacopan label: “Avacopan exposure is increased when co-administered with strong CYP3A4 enzyme inhibitors such as itraconazole.”
Check it at the source: the avacopan FDA label on DailyMed (effective June 2, 2026, ChemoCentryx, Inc.); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the avacopan label say about itraconazole?
Avacopan label, drug interactionsAvacopan exposure is increased when co-administered with strong CYP3A4 enzyme inhibitors such as itraconazole [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (TAVNEOS), ChemoCentryx, Inc., effective June 2, 2026 (SPL set c93cbc0b-29a3-46a5-9c85-41815ea5cf4a), via openFDA; the full label on DailyMed
What does the itraconazole label say about avacopan?
Itraconazole's label (effective July 13, 2026) and its 1 other brand-application label do not name avacopan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Avacopan | Itraconazole | |
|---|---|---|
| Labeled for | n/a | Fungal infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.910 per capsule 100 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once