What the FDA labels say about taking them together
Atropine and tiotropium
Tiotropium's FDA label of November 10, 2025 names atropine in its warnings and precautions section; the atropine labels PlainMeds reads (4) do not name tiotropium. The tiotropium label: “Given the similar structural formula of atropine to tiotropium, patients with a history of hypersensitivity reactions to atropine or its derivatives should be closely monitored for similar hypersensitivity reactions to …”
Check it at the source: the atropine FDA label on DailyMed (effective May 18, 2026, Hospira, Inc.); the tiotropium FDA label on DailyMed (effective November 10, 2025, Boehringer Ingelheim Pharmaceuticals, Inc.).
What does the atropine label say about tiotropium?
Atropine's label (effective May 18, 2026) and its 3 other brand-application labels do not name tiotropium in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Atropine Sulfate), Hospira, Inc., effective May 18, 2026 (SPL set ad8916e7-206e-409e-2582-30d072845dd4), via openFDA; the full label on DailyMed
What does the tiotropium label say about atropine?
Tiotropium label, warnings and precautionsGiven the similar structural formula of atropine to tiotropium, patients with a history of hypersensitivity reactions to atropine or its derivatives should be closely monitored for similar hypersensitivity reactions to SPIRIVA HANDIHALER.
Source: FDA drug label (Spiriva Respimat, NDA021936), Boehringer Ingelheim Pharmaceuticals, Inc., effective August 17, 2026 (SPL set 7b656b14-fcaa-2741-f6f0-e0be48971c02), via openFDA
Source: FDA drug label (Spiriva HandiHaler), Boehringer Ingelheim Pharmaceuticals, Inc., effective November 10, 2025 (SPL set 820839ef-e53d-47e8-a3b9-d911ff92e6a9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atropine | Tiotropium | |
|---|---|---|
| Labeled for | n/a | COPD, Asthma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $7.74 per mL 1% eye drops | $11.81 per capsule 18 mcg capsule-inhaler |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once