What the FDA labels say about taking them together
Atropine and pralidoxime
Atropine's FDA label (N/A) of February 18, 2026 names pralidoxime in its drug interactions section, and pralidoxime's label names atropine too.
Check it at the source: the atropine FDA label on DailyMed (effective May 18, 2026, Hospira, Inc.); the pralidoxime FDA label on DailyMed (effective April 1, 2026, Baxter Healthcare Corporation).
What does the atropine label say about pralidoxime?
N/A label (Rafa Laboratories, Ltd., February 18, 2026), drug interactionsPralidoxime When atropine and pralidoxime are used together, the signs of atropinization (flushing, mydriasis, tachycardia, dryness of the mouth and nose) may occur earlier than might be expected when atropine is used alone because pralidoxime may potentiate the effect of atropine.
Source: FDA drug label (N/A, NDA212319), Rafa Laboratories, Ltd., effective February 18, 2026 (SPL set 4a4fa6e8-0e0a-0e76-e054-00144ff8d46c), via openFDA
Source: FDA drug label (Atropine Sulfate), Hospira, Inc., effective May 18, 2026 (SPL set ad8916e7-206e-409e-2582-30d072845dd4), via openFDA; the full label on DailyMed
What does the pralidoxime label say about atropine?
Pralidoxime label, drug interactionsDrug Interactions When atropine and pralidoxime chloride are used together, the signs of atropinization (flushing, mydriasis, tachycardia, dryness of the mouth and nose) may occur earlier than might be expected when atropine is used alone.
Source: FDA drug label (Protopam Chloride), Baxter Healthcare Corporation, effective April 1, 2026 (SPL set 2741d8fd-51c2-46be-880b-99f2b20a6137), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atropine | Pralidoxime | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $7.74 per mL 1% eye drops | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once