What the FDA labels say about taking them together
Atropine and clonidine
Clonidine's FDA label (Javadin) of October 24, 2025 names atropine in its warnings and precautions section; the atropine labels PlainMeds reads (4) do not name clonidine.
Check it at the source: the atropine FDA label on DailyMed (effective May 18, 2026, Hospira, Inc.); the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.).
What does the atropine label say about clonidine?
Atropine's label (effective May 18, 2026) and its 3 other brand-application labels do not name clonidine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Atropine Sulfate), Hospira, Inc., effective May 18, 2026 (SPL set ad8916e7-206e-409e-2582-30d072845dd4), via openFDA; the full label on DailyMed
What does the clonidine label say about atropine?
Javadin label (Azurity Pharmaceuticals, Inc., October 24, 2025), warnings and precautionsThere have been post-marketing reports of patients with conduction abnormalities and/or taking other sympatholytic drugs who developed severe bradycardia requiring intravenous (IV) atropine, IV isoproterenol, and temporary cardiac pacing while taking clonidine.
Source: FDA drug label (Javadin, NDA220256), Azurity Pharmaceuticals, Inc., effective October 24, 2025 (SPL set c36d94f5-a30d-4997-b141-e79a4ea45ecf), via openFDA
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atropine | Clonidine | |
|---|---|---|
| Labeled for | n/a | High blood pressure, ADHD, Pain |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $7.74 per mL 1% eye drops | $0.0241 per tablet 0.1 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once