What the FDA labels say about taking them together
Atorvastatin and siltuximab
Siltuximab's FDA label of August 27, 2024 names atorvastatin in its drug interactions section; the atorvastatin labels PlainMeds reads (2) do not name siltuximab. The siltuximab label: “Exercise caution when SYLVANT is co-administered with CYP3A4 substrate drugs where a decrease in effectiveness would be undesirable.”
Check it at the source: the atorvastatin FDA label on DailyMed (effective April 15, 2024, Viatris Specialty LLC); the siltuximab FDA label on DailyMed (effective August 27, 2024).
What does the atorvastatin label say about siltuximab?
Atorvastatin's label (effective April 15, 2024) and its 1 other brand-application label do not name siltuximab in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lipitor), NDA020702 (Upjohn), as published by Viatris Specialty LLC, effective April 15, 2024 (SPL set a60cc18b-0631-4cf0-b021-9f52224ece65), via openFDA; the full label on DailyMed
What does the siltuximab label say about atorvastatin?
Siltuximab label, drug interactionsExercise caution when SYLVANT is co-administered with CYP3A4 substrate drugs where a decrease in effectiveness would be undesirable (e.g., oral contraceptives, lovastatin, atorvastatin).
Source: FDA drug label (Sylvant), Recordati Rare Diseases, Inc., effective August 27, 2024 (SPL set 8d663642-f52e-49c0-a023-2da083fdfc0b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atorvastatin | Siltuximab | |
|---|---|---|
| Labeled for | High cholesterol, Angina, High triglycerides, Heart attack and coronary artery disease | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0228 per tablet 10 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once