What the FDA labels say about taking them together
Atorvastatin and resmetirom
Resmetirom's FDA label of July 29, 2026 names atorvastatin in its drug interactions section; the atorvastatin labels PlainMeds reads (2) do not name resmetirom. The resmetirom label: “Clinical Impact; REZDIFFRA increased plasma concentrations of some statins, which may increase the risk of adverse reactions related to these drugs.”
Check it at the source: the atorvastatin FDA label on DailyMed (effective April 15, 2024, Viatris Specialty LLC); the resmetirom FDA label on DailyMed (effective July 29, 2026, Madrigal Pharmaceuticals, Inc.).
What does the atorvastatin label say about resmetirom?
Atorvastatin's label (effective April 15, 2024) and its 1 other brand-application label do not name resmetirom in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lipitor), NDA020702 (Upjohn), as published by Viatris Specialty LLC, effective April 15, 2024 (SPL set a60cc18b-0631-4cf0-b021-9f52224ece65), via openFDA; the full label on DailyMed
What does the resmetirom label say about atorvastatin?
Resmetirom label, drug interactionsClinical Impact; REZDIFFRA increased plasma concentrations of some statins (atorvastatin, pravastatin, rosuvastatin and simvastatin) [see ], which may increase the risk of adverse reactions related to these drugs.
Resmetirom label, warnings and precautionsInteraction with Certain Statins An increase in exposure of atorvastatin, pravastatin, rosuvastatin and simvastatin was observed when concomitantly administered with REZDIFFRA [see Clinical Pharmacology (12.3) ], which may increase the risk of adverse reactions related to these drugs.
Source: FDA drug label (REZDIFFRA), Madrigal Pharmaceuticals, Inc., effective July 29, 2026 (SPL set e67ea09f-a840-439c-86c8-f98585f978b2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atorvastatin | Resmetirom | |
|---|---|---|
| Labeled for | High cholesterol, Angina, High triglycerides, Heart attack and coronary artery disease | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0228 per tablet 10 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once