What the FDA labels say about taking them together
Atorvastatin and efavirenz
Atorvastatin's FDA label of April 15, 2024 names efavirenz in its drug interactions section, and efavirenz's label names atorvastatin too. The efavirenz label: “Plasma concentrations of atorvastatin, pravastatin and simvastatin decreased. Consult the full prescribing information for the HMG-CoA reductase inhibitor for guidance on individualizing the dose.”
Check it at the source: the atorvastatin FDA label on DailyMed (effective April 15, 2024, Viatris Specialty LLC); the efavirenz FDA label on DailyMed (effective March 31, 2024, Cipla USA Inc.).
What does the atorvastatin label say about efavirenz?
Atorvastatin label, drug interactionsNamed in a table that the FDA label file prints without its column breaks; the full label shows the table.
Source: FDA drug label (Atorvaliq, NDA213260), CMP Pharma, Inc., effective April 27, 2024 (SPL set 41fca2d8-7f3f-45b9-8974-81b89accc211), via openFDA
Source: FDA drug label (Lipitor), NDA020702 (Upjohn), as published by Viatris Specialty LLC, effective April 15, 2024 (SPL set a60cc18b-0631-4cf0-b021-9f52224ece65), via openFDA; the full label on DailyMed
What does the efavirenz label say about atorvastatin?
Efavirenz label, drug interactionsConcomitant Drug Class/Drug Name: HMG-CoA reductase inhibitors: Atorvastatin Pravastatin Simvastatin; Effect: ↓ atorvastatin * ↓ pravastatin * ↓ simvastatin *; Clinical Comment: Plasma concentrations of atorvastatin, pravastatin and simvastatin decreased. Consult the full prescribing information for the HMG-CoA reductase inhibitor for guidance on individualizing the dose.
Source: FDA drug label (Efavirenz), Cipla USA Inc., effective March 31, 2024 (SPL set 92603fa5-7a2c-4bfb-9a70-aadb4fba952c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atorvastatin | Efavirenz | |
|---|---|---|
| Labeled for | High cholesterol, Angina, High triglycerides, Heart attack and coronary artery disease | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0228 per tablet 10 mg tablet | $1.28 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once