What the FDA labels say about taking them together
Atorvastatin and drospirenone/ethinyl estradiol/levomefolate
Drospirenone/ethinyl estradiol/levomefolate's FDA label of March 4, 2026 names atorvastatin in its drug interactions section; the atorvastatin labels PlainMeds reads (2) do not name drospirenone/ethinyl estradiol/levomefolate. The drospirenone/ethinyl estradiol/levomefolate label: “Substances increasing the plasma concentrations of COCs: Co-administration of atorvastatin and certain COCs containing EE increase AUC values for EE by approximately 20%.”
Check it at the source: the atorvastatin FDA label on DailyMed (effective April 15, 2024, Viatris Specialty LLC); the drospirenone/ethinyl estradiol/levomefolate FDA label on DailyMed (effective March 4, 2026, Bayer HealthCare Pharmaceuticals Inc.).
What does the atorvastatin label say about drospirenone/ethinyl estradiol/levomefolate?
Atorvastatin's label (effective April 15, 2024) and its 1 other brand-application label do not name drospirenone/ethinyl estradiol/levomefolate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lipitor), NDA020702 (Upjohn), as published by Viatris Specialty LLC, effective April 15, 2024 (SPL set a60cc18b-0631-4cf0-b021-9f52224ece65), via openFDA; the full label on DailyMed
What does the drospirenone/ethinyl estradiol/levomefolate label say about atorvastatin?
Drospirenone/ethinyl estradiol/levomefolate label, drug interactionsSubstances increasing the plasma concentrations of COCs: Co-administration of atorvastatin with certain COCs containing EE increase AUC values for EE by approximately 20%.
Source: FDA drug label (Beyaz, NDA022532), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 8132454a-6135-4bac-b206-83a55eb8dbc6), via openFDA
Source: FDA drug label (Safyral), Bayer HealthCare Pharmaceuticals Inc., effective March 4, 2026 (SPL set 97563516-306a-4e17-9690-edbda49ecd83), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atorvastatin | Drospirenone/ethinyl estradiol/levomefolate | |
|---|---|---|
| Labeled for | High cholesterol, Angina, High triglycerides, Heart attack and coronary artery disease | Birth control, Acne |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0228 per tablet 10 mg tablet | $1.38 per unit 3-0.02-0.451 |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once