What the FDA labels say about taking them together
Atomoxetine and midazolam
Atomoxetine's FDA label of May 25, 2026 names midazolam in its drug interactions section; the midazolam labels PlainMeds reads (4) do not name atomoxetine. The atomoxetine label: “CYP3A Substrate (e.g., Midazolam) – Coadministration of atomoxetine (60 mg BID for 12 days) with midazolam, a model compound for CYP3A4 metabolized drugs (single dose of 5 mg), resulted in 15% increase in AUC of …”
Check it at the source: the atomoxetine FDA label on DailyMed (effective May 25, 2026, Camber Pharmaceuticals, Inc.); the midazolam FDA label on DailyMed (effective January 1, 2024, Fresenius Kabi USA, LLC).
What does the atomoxetine label say about midazolam?
Atomoxetine label, drug interactionsCYP3A Substrate (e.g., Midazolam) – Coadministration of atomoxetine (60 mg BID for 12 days) with midazolam, a model compound for CYP3A4 metabolized drugs (single dose of 5 mg), resulted in 15% increase in AUC of midazolam.
Source: FDA drug label (Atomoxetine), ANDA202682 (Hetero Labs Ltd V), as published by Camber Pharmaceuticals, Inc., effective May 25, 2026 (SPL set f266ab7b-5a68-42b5-b204-e3249bea0aed), via openFDA; the full label on DailyMed
What does the midazolam label say about atomoxetine?
Midazolam's label (effective January 1, 2024) and its 3 other brand-application labels do not name atomoxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Midazolam), Fresenius Kabi USA, LLC, effective January 1, 2024 (SPL set 1cc9ba6e-fa1b-405e-9de8-720c567b2a73), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atomoxetine | Midazolam | |
|---|---|---|
| Labeled for | ADHD | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.442 per capsule 40 mg capsule | $0.233 per mL 2 mg/2 mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once