What the FDA labels say about taking them together
Atogepant and topiramate
Atogepant's FDA label of September 30, 2025 names topiramate in its drug interactions section; the topiramate labels PlainMeds reads (4) do not name atogepant. The atogepant label: “Coadministration of QULIPTA with steady-state topiramate, a weak CYP3A4 inducer, resulted in decreased exposure of atogepant in healthy subjects.”
Check it at the source: the atogepant FDA label on DailyMed (effective September 30, 2025, AbbVie Inc.); the topiramate FDA label on DailyMed (effective June 1, 2026, Sun Pharmaceutical Industries, Inc.).
What does the atogepant label say about topiramate?
Atogepant label, drug interactionsCoadministration of QULIPTA with steady-state topiramate, a weak CYP3A4 inducer, resulted in decreased exposure of atogepant in healthy subjects [see Clinical Phar macology ( 12.3 )].
Source: FDA drug label (Qulipta), AbbVie Inc., effective September 30, 2025 (SPL set 8c8ab8f4-32bd-497a-befa-70c8a51d8d52), via openFDA; the full label on DailyMed
What does the topiramate label say about atogepant?
Topiramate's label (effective June 1, 2026) and its 3 other brand-application labels do not name atogepant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Topiramate), Sun Pharmaceutical Industries, Inc., effective June 1, 2026 (SPL set 3c909a53-ae66-4b28-a741-b60bb25a69cf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atogepant | Topiramate | |
|---|---|---|
| Labeled for | Migraine | Seizures and epilepsy, Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $38.36 per tablet 10 mg tablet | $0.0567 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once