What the FDA labels say about taking them together
Atazanavir/cobicistat and fluvastatin
Atazanavir/cobicistat's FDA label of May 12, 2025 names fluvastatin in its drug interactions section; the fluvastatin labels PlainMeds reads (2) do not name atazanavir/cobicistat. The atazanavir/cobicistat label: “Coadministration of EVOTAZ with atorvastatin is not recommended. For HMG-CoA reductase inhibitors that are not contraindicated with EVOTAZ, start with the lowest recommended dose and titrate while monitoring for safety …”
Check it at the source: the atazanavir/cobicistat FDA label on DailyMed (effective May 12, 2025, E.R. Squibb & Sons, L.L.C.); the fluvastatin FDA label on DailyMed (effective April 21, 2025, Teva Pharmaceuticals USA, Inc.).
What does the atazanavir/cobicistat label say about fluvastatin?
Atazanavir/cobicistat label, drug interactionsConcomitant Drug Class/Specific Drugs: Other HMG-CoA reductase inhibitors: atorvastatin, fluvastatin, pravastatin, rosuvastatin; Effect b on Concentration: ↑ HMG-CoA reductase inhibitors; Clinical Comment: Coadministration of EVOTAZ with atorvastatin is not recommended. For HMG-CoA reductase inhibitors that are not contraindicated with EVOTAZ, start with the lowest recommended dose and titrate while monitoring for safety (e.g., myopathy). Dosage recommendations with rosuvastatin are as follows. Rosuvastatin dose should not exceed 10 mg/day.
Source: FDA drug label (EVOTAZ), NDA206353 (Bristol), as published by E.R. Squibb & Sons, L.L.C., effective May 12, 2025 (SPL set 83db29d7-5d85-49d6-8cb6-740473365cf8), via openFDA; the full label on DailyMed
What does the fluvastatin label say about atazanavir/cobicistat?
Fluvastatin's label (effective April 21, 2025) and its 1 other brand-application label do not name atazanavir/cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fluvastatin), Teva Pharmaceuticals USA, Inc., effective April 21, 2025 (SPL set aad8b373-0aec-4efb-8e61-3d8114b31127), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atazanavir/cobicistat | Fluvastatin | |
|---|---|---|
| Labeled for | HIV | High cholesterol |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $52.05 per tablet 300 mg-150 mg tablet | $2.88 per tablet 80 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once