What the FDA labels say about taking them together
Atazanavir and tacrolimus
Atazanavir's FDA label (Reyataz) of December 5, 2024 names tacrolimus in its drug interactions section; the tacrolimus labels PlainMeds reads (4) do not name atazanavir. The atazanavir label: “Therapeutic concentration monitoring is recommended for these immunosuppressants when coadministered with REYATAZ.”
Check it at the source: the atazanavir FDA label on DailyMed (effective August 6, 2025, Aurobindo Pharma Limited); the tacrolimus FDA label on DailyMed (effective July 17, 2026, Stellon Biotech Inc.).
What does the atazanavir label say about tacrolimus?
Reyataz label (E.R. Squibb & Sons, L.L.C., December 5, 2024), drug interactionsConcomitant Drug Class/Specific Drugs: Immunosuppressants: cyclosporine, sirolimus, tacrolimus; Effect on Concentration of Atazanavir or Concomitant Drug: ↑ immunosuppressants; Clinical Comment: Therapeutic concentration monitoring is recommended for these immunosuppressants when coadministered with REYATAZ.
Source: FDA drug label (Reyataz, NDA021567), E.R. Squibb & Sons, L.L.C., effective December 5, 2024 (SPL set 165cff62-b284-4a27-a65d-9ec8a5bfcdd8), via openFDA
Source: FDA drug label (Atazanavir Sulfate), Aurobindo Pharma Limited, effective August 6, 2025 (SPL set 7fbea274-d6b5-4faa-bbf0-05fefab42114), via openFDA; the full label on DailyMed
What does the tacrolimus label say about atazanavir?
Tacrolimus's label (effective July 17, 2026) and its 3 other brand-application labels do not name atazanavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tacrolimus), Stellon Biotech Inc., effective July 17, 2026 (SPL set 6b89e8a4-9f11-42e3-8e79-fe617e7c461f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atazanavir | Tacrolimus | |
|---|---|---|
| Labeled for | HIV | Organ transplant rejection, Eczema (atopic dermatitis) |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $2.23 per capsule 300 mg capsule | $0.970 per gram 0.1% ointment |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once