What the FDA labels say about taking them together
Atazanavir and simvastatin
Atazanavir's FDA label of August 6, 2025 names simvastatin in its contraindications section; the simvastatin label PlainMeds reads does not name atazanavir. The atazanavir label: “Coadministration of REYATAZ with lovastatin or simvastatin is contraindicated. This is due to the potential for serious reactions such as myopathy, including rhabdomyolysis.”
Check it at the source: the atazanavir FDA label on DailyMed (effective August 6, 2025, Aurobindo Pharma Limited); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the atazanavir label say about simvastatin?
Atazanavir label, contraindicationsDrug Class: Lipid-Modifying Agents:; Drugs within class that are contraindicated with atazanavir capsules: Lomitapide, lovastatin, simvastatin
Atazanavir label, drug interactionsConcomitant Drug Class/Specific Drugs: Lipid-modifying agents HMG-CoA reductase inhibitors: lovastatin, simvastatin; Effect on Concentration of Atazanavir or Concomitant Drug: ↑ lovastatin ↑ simvastatin; Clinical Comment: Coadministration of atazanavir with lovastatin or simvastatin is contraindicated. This is due to the potential for serious reactions such as myopathy, including rhabdomyolysis [see ].
Source: FDA drug label (Reyataz, NDA021567), E.R. Squibb & Sons, L.L.C., effective December 5, 2024 (SPL set 165cff62-b284-4a27-a65d-9ec8a5bfcdd8), via openFDA
Source: FDA drug label (Atazanavir Sulfate), Aurobindo Pharma Limited, effective August 6, 2025 (SPL set 7fbea274-d6b5-4faa-bbf0-05fefab42114), via openFDA; the full label on DailyMed
What does the simvastatin label say about atazanavir?
Simvastatin's label (effective March 28, 2025) does not name atazanavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atazanavir | Simvastatin | |
|---|---|---|
| Labeled for | HIV | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $2.23 per capsule 300 mg capsule | $0.0321 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once