What the FDA labels say about taking them together
Atazanavir and sildenafil
Atazanavir's FDA label of August 6, 2025 names sildenafil in its contraindications section; the sildenafil labels PlainMeds reads (4) do not name atazanavir. The atazanavir label: “Drug Class: Phosphodiesterase-5 (PDE-5) Inhibitor; Drugs within class that are contraindicated with REYATAZ: Sildenafil b when dosed as REVATIO ® for the treatment of pulmonary arterial hypertension”
Check it at the source: the atazanavir FDA label on DailyMed (effective August 6, 2025, Aurobindo Pharma Limited); the sildenafil FDA label on DailyMed (effective November 17, 2023, Viatris Specialty LLC).
What does the atazanavir label say about sildenafil?
Atazanavir label, contraindicationsDrug Class: Phosphodiesterase-5 (PDE-5) Inhibitor; Drugs within class that are contraindicated with atazanavir capsules: Sildenafil b when dosed as REVATIO ® for the treatment of pulmonary arterial hypertension
Source: FDA drug label (Reyataz, NDA021567), E.R. Squibb & Sons, L.L.C., effective December 5, 2024 (SPL set 165cff62-b284-4a27-a65d-9ec8a5bfcdd8), via openFDA
Source: FDA drug label (Atazanavir Sulfate), Aurobindo Pharma Limited, effective August 6, 2025 (SPL set 7fbea274-d6b5-4faa-bbf0-05fefab42114), via openFDA; the full label on DailyMed
What does the sildenafil label say about atazanavir?
Sildenafil's label (effective November 17, 2023) and its 3 other brand-application labels do not name atazanavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Viagra), Viatris Specialty LLC, effective November 17, 2023 (SPL set d905dc8d-917f-4ea3-a4ee-a1ecf6967d4e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atazanavir | Sildenafil | |
|---|---|---|
| Labeled for | HIV | Erectile dysfunction, Pulmonary arterial hypertension |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $2.23 per capsule 300 mg capsule | $0.132 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once