What the FDA labels say about taking them together
Atazanavir and rabeprazole
Rabeprazole's FDA label of January 27, 2026 names atazanavir in its drug interactions section; the atazanavir labels PlainMeds reads (2) do not name rabeprazole. The rabeprazole label: “The effect of PPI on antiretroviral drugs is variable. The clinical importance and the mechanisms behind these interactions are not always known. …”
Check it at the source: the atazanavir FDA label on DailyMed (effective August 6, 2025, Aurobindo Pharma Limited); the rabeprazole FDA label on DailyMed (effective January 27, 2026, Waylis Therapeutics LLC).
What does the atazanavir label say about rabeprazole?
Atazanavir's label (effective August 6, 2025) and its 1 other brand-application label do not name rabeprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Atazanavir Sulfate), Aurobindo Pharma Limited, effective August 6, 2025 (SPL set 7fbea274-d6b5-4faa-bbf0-05fefab42114), via openFDA; the full label on DailyMed
What does the rabeprazole label say about atazanavir?
Rabeprazole label, drug interactionsAntiretrovirals Clinical Impact: The effect of PPI on antiretroviral drugs is variable. The clinical importance and the mechanisms behind these interactions are not always known. Decreased exposure of some antiretroviral drugs (…) when used concomitantly with rabeprazole may reduce antiviral effect and promote the development of drug resistance. … Intervention: Rilpivirine-containing products: Concomitant use with ACIPHEX delayed-release tablets is contraindicated [see ]. See prescribing information. Atazanavir: See prescribing information for atazanavir for dosing information. Nelfinavir: Avoid concomitant use with ACIPHEX delayed-release tablets. …
Source: FDA drug label (Aciphex), Waylis Therapeutics LLC, effective January 27, 2026 (SPL set 1eb38279-0237-4967-be7a-c53a826c1138), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atazanavir | Rabeprazole | |
|---|---|---|
| Labeled for | HIV | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $2.23 per capsule 300 mg capsule | $0.224 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once