What the FDA labels say about taking them together
Atazanavir and lansoprazole
Lansoprazole's FDA label of June 24, 2025 names atazanavir in its drug interactions (prescription label) section; the atazanavir labels PlainMeds reads (2) do not name lansoprazole. The lansoprazole label: “The effect of PPIs on antiretroviral drugs is variable. The clinical importance and the mechanisms behind these interactions are not always known. …”
Check it at the source: the atazanavir FDA label on DailyMed (effective August 6, 2025, Aurobindo Pharma Limited); the lansoprazole FDA label on DailyMed (effective June 24, 2025, L. Perrigo Company).
What does the atazanavir label say about lansoprazole?
Atazanavir's label (effective August 6, 2025) and its 1 other brand-application label do not name lansoprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Atazanavir Sulfate), Aurobindo Pharma Limited, effective August 6, 2025 (SPL set 7fbea274-d6b5-4faa-bbf0-05fefab42114), via openFDA; the full label on DailyMed
What does the lansoprazole label say about atazanavir?
Lansoprazole label, drug interactions (prescription label)Antiretrovirals Clinical Impact: The effect of PPIs on antiretroviral drugs is variable. The clinical importance and the mechanisms behind these interactions are not always known. Decreased exposure of some antiretroviral drugs (…) when used concomitantly with lansoprazole may reduce antiviral effect and promote the development of drug resistance. … Intervention: Rilpivirine-containing products: Concomitant use with PREVACID or PREVACID SoluTab is contraindicated [see ]. See prescribing information. Atazanavir: See prescribing information for atazanavir for dosing information. Nelfinavir: Avoid concomitant use with PREVACID or PREVACID SoluTab. …
Source: FDA drug label (Prevacid 24 HR), L. Perrigo Company, effective June 24, 2025 (SPL set 205c9c1e-b422-4e86-a4b0-714b608adc19), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atazanavir | Lansoprazole | |
|---|---|---|
| Labeled for | HIV | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $2.23 per capsule 300 mg capsule | $0.106 per capsule 30 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once