What the FDA labels say about taking them together
Atazanavir and famotidine/ibuprofen
Famotidine/ibuprofen's FDA label of July 3, 2025 names atazanavir in its drug interactions section; the atazanavir labels PlainMeds reads (2) do not name famotidine/ibuprofen. The famotidine/ibuprofen label: “Because famotidine lowers intra-gastric acidity, this may result in reduced absorption and loss of efficacy of concomitant drugs.”
Check it at the source: the atazanavir FDA label on DailyMed (effective August 6, 2025, Aurobindo Pharma Limited); the famotidine/ibuprofen FDA label on DailyMed (effective July 3, 2025, Aurobindo Pharma Limited).
What does the atazanavir label say about famotidine/ibuprofen?
Atazanavir's label (effective August 6, 2025) and its 1 other brand-application label do not name famotidine/ibuprofen in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Atazanavir Sulfate), Aurobindo Pharma Limited, effective August 6, 2025 (SPL set 7fbea274-d6b5-4faa-bbf0-05fefab42114), via openFDA; the full label on DailyMed
What does the famotidine/ibuprofen label say about atazanavir?
Famotidine/ibuprofen label, drug interactionsDrugs Dependent on Gastric pH for Absorption Clinical Impact: Because famotidine lowers intra-gastric acidity, this may result in reduced absorption and loss of efficacy of concomitant drugs. … other drugs whose absorption is dependent on gastric pH, refer to their prescribing information (e.g., atazanavir, erlotinib, ketoconazole, itraconazole, nilotinib, ledipasvir/sofosbuvir, and rilpivirine).
Source: FDA drug label (Ibuprofen and famotidine), Aurobindo Pharma Limited, effective July 3, 2025 (SPL set 21688404-41fb-487e-8ba0-aea4431a42fa), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atazanavir | Famotidine/ibuprofen | |
|---|---|---|
| Labeled for | HIV | Osteoarthritis, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $2.23 per capsule 300 mg capsule | $0.714 per unit 800-26.6 mg |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once