What the FDA labels say about taking them together
Atazanavir and elagolix
Atazanavir's FDA label of August 6, 2025 names elagolix in its drug interactions section; the elagolix label PlainMeds reads does not name atazanavir. The atazanavir label: “Coadministration of elagolix and REYATAZ with or without ritonavir is not recommended due to the potential of loss of virologic response and the potential risk of adverse events such as bone loss and hepatic …”
Check it at the source: the atazanavir FDA label on DailyMed (effective August 6, 2025, Aurobindo Pharma Limited); the elagolix FDA label on DailyMed (effective December 19, 2025, AbbVie Inc.).
What does the atazanavir label say about elagolix?
Atazanavir label, drug interactionsConcomitant Drug Class/Specific Drugs: Gonadotropin-releasing hormone Receptor (GnRH) Antagonists: elagolix; Effect on Concentration of Atazanavir or Concomitant Drug: ↓ atazanavir ↑ elagolix; Clinical Comment: Coadministration of elagolix and atazanavir with or without ritonavir is not recommended due to the potential of loss of virologic response and the potential risk of adverse events such as bone loss and hepatic transaminase elevations associated with elagolix. …
Source: FDA drug label (Reyataz, NDA021567), E.R. Squibb & Sons, L.L.C., effective December 5, 2024 (SPL set 165cff62-b284-4a27-a65d-9ec8a5bfcdd8), via openFDA
Source: FDA drug label (Atazanavir Sulfate), Aurobindo Pharma Limited, effective August 6, 2025 (SPL set 7fbea274-d6b5-4faa-bbf0-05fefab42114), via openFDA; the full label on DailyMed
What does the elagolix label say about atazanavir?
Elagolix's label (effective December 19, 2025) does not name atazanavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Orilissa), AbbVie Inc., effective December 19, 2025 (SPL set a86757b3-09c5-fd3b-1223-244e94f50a66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atazanavir | Elagolix | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $2.23 per capsule 300 mg capsule | $43.81 per tablet 150 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once