What the FDA labels say about taking them together
Atazanavir and avanafil
Avanafil's FDA label of December 17, 2025 names atazanavir in its warnings and precautions section; the atazanavir labels PlainMeds reads (2) do not name avanafil. The avanafil label: “For patients taking concomitant strong CYP3A4 inhibitors, do not use avanafil.”
Check it at the source: the atazanavir FDA label on DailyMed (effective August 6, 2025, Aurobindo Pharma Limited); the avanafil FDA label on DailyMed (effective December 17, 2025, Camber Pharmaceuticals, Inc.).
What does the atazanavir label say about avanafil?
Atazanavir's label (effective August 6, 2025) and its 1 other brand-application label do not name avanafil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Atazanavir Sulfate), Aurobindo Pharma Limited, effective August 6, 2025 (SPL set 7fbea274-d6b5-4faa-bbf0-05fefab42114), via openFDA; the full label on DailyMed
What does the avanafil label say about atazanavir?
Avanafil label, warnings and precautionsFor patients taking concomitant strong CYP3A4 inhibitors (including ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir and telithromycin), do not use avanafil [see Drug Interactions ( 7.2 )].
Source: FDA drug label (Avanafil), ANDA209266 (Hetero Labs Ltd V), as published by Camber Pharmaceuticals, Inc., effective December 17, 2025 (SPL set 1d04e17d-7399-430a-a8bb-fa1912b155e9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atazanavir | Avanafil | |
|---|---|---|
| Labeled for | HIV | Erectile dysfunction |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $2.23 per capsule 300 mg capsule | $50.00 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once