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What the FDA labels say about taking them together

Atazanavir and atorvastatin

Atazanavir's FDA label of August 6, 2025 names atorvastatin in its drug interactions section; the atorvastatin labels PlainMeds reads (2) do not name atazanavir. The atazanavir label: “Titrate atorvastatin dose carefully and use the lowest necessary dose. Rosuvastatin dose should not exceed 10 mg/day. The risk of myopathy, including rhabdomyolysis, may be increased when HIV protease inhibitors …”

Check it at the source: the atazanavir FDA label on DailyMed (effective August 6, 2025, Aurobindo Pharma Limited); the atorvastatin FDA label on DailyMed (effective April 15, 2024, Viatris Specialty LLC).

What does the atazanavir label say about atorvastatin?

Atazanavir label, drug interactions

Concomitant Drug Class/Specific Drugs: atorvastatin, rosuvastatin; Effect on Concentration of Atazanavir or Concomitant Drug: ↑ atorvastatin ↑ rosuvastatin; Clinical Comment: Titrate atorvastatin dose carefully and use the lowest necessary dose. Rosuvastatin dose should not exceed 10 mg/day. The risk of myopathy, including rhabdomyolysis, may be increased when HIV protease inhibitors, including atazanavir, are used in combination with these drugs.

Source: FDA drug label (Atazanavir Sulfate), Aurobindo Pharma Limited, effective August 6, 2025 (SPL set 7fbea274-d6b5-4faa-bbf0-05fefab42114), via openFDA; the full label on DailyMed

What does the atorvastatin label say about atazanavir?

Atorvastatin's label (effective April 15, 2024) and its 1 other brand-application label do not name atazanavir in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Lipitor), NDA020702 (Upjohn), as published by Viatris Specialty LLC, effective April 15, 2024 (SPL set a60cc18b-0631-4cf0-b021-9f52224ece65), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

4Atazanavir generic labelers
59Atorvastatin generic labelers
AtazanavirAtorvastatin
Labeled forHIVHigh cholesterol, Angina, High triglycerides, Heart attack and coronary artery disease
Boxed warningNoNo
Pharmacy cost (NADAC)$2.23 per capsule 300 mg capsule$0.0228 per tablet 10 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?