What the FDA labels say about taking them together
Aspirin, butalbital, caffeine and codeine and ramipril
Aspirin, butalbital, caffeine and codeine's FDA label of May 27, 2026 names ramipril in its drug interactions section; ramipril's label does not name aspirin, butalbital, caffeine and codeine itself but warns about its class (Barbiturates, Stimulants, NSAIDs (nonsteroidal anti-inflammatory drugs), Opioids (opioid agonists), platelet aggregation inhibitors).
Check it at the source: the aspirin, butalbital, caffeine and codeine FDA label on DailyMed (effective May 27, 2026, Bryant Ranch Prepack); the ramipril FDA label on DailyMed (effective August 24, 2026, Lupin Pharmaceuticals, Inc.).
What does the aspirin, butalbital, caffeine and codeine label say about ramipril?
Aspirin, butalbital, caffeine and codeine label, drug interactionsAngiotensin Converting Enzyme (ACE) Inhibitors Clinical Impact: The hyponatremic and hypotensive effects of ACE inhibitors may be diminished by the concomitant administration of aspirin due to its indirect effect on the renin-angiotensin conversion pathway. Intervention: Use caution if using concomitantly. Evaluate the blood pressure and renal function of patients. Examples: Ramipril, captopril
Source: FDA drug label (BUTALBITAL, ASPIRIN, CAFFEINE AND CODEINE PHOSPHATE), ANDA075231 (Lgm Pharma), as published by Bryant Ranch Prepack, effective May 27, 2026 (SPL set 95a33c9b-79a6-47c7-8433-fc217950b88f), via openFDA; the full label on DailyMed
What does the ramipril label say about aspirin, butalbital, caffeine and codeine?
Ramipril's label does not name aspirin, butalbital, caffeine and codeine itself; it warns about its class (Barbiturates, Stimulants, NSAIDs (nonsteroidal anti-inflammatory drugs), Opioids (opioid agonists), platelet aggregation inhibitors):
Ramipril label, drug interactionsNitritoid reactions (symptoms include facial flushing, nausea, vomiting and hypotension) have been reported rarely in patients on therapy with injectable gold (sodium aurothiomalate) and concomitant ACE inhibitor therapy including ramipril. Agents including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE …
Ramipril label, drug interactionsNSAIDS use may lead to increased risk of renal impairment and loss of antihypertensive effect ( 7.6 ). mTOR inhibitor or neprilysin inhibitor use may increase angioedema risk ( 7.7 ).
Source: FDA drug label (Ramipril), Lupin Pharmaceuticals, Inc., effective August 24, 2026 (SPL set a8cdec12-81d1-4ef4-82c0-d05d93c37a07), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin, butalbital, caffeine and codeine | Ramipril | |
|---|---|---|
| Labeled for | Pain | High blood pressure, Heart attack and coronary artery disease |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.00 per capsule Ascomp with codeine capsule | $0.0707 per capsule 10 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once