What the FDA labels say about taking them together
Aspirin, butalbital, caffeine and codeine and metoprolol
Aspirin, butalbital, caffeine and codeine's FDA label of May 27, 2026 names metoprolol in its drug interactions section; the metoprolol labels PlainMeds reads (4) do not name aspirin, butalbital, caffeine and codeine. The aspirin, butalbital, caffeine and codeine label: “The hypotensive effects of beta blockers may be diminished by the concomitant administration of aspirin due to inhibition of renal prostaglandins, leading to decreased renal blood flow, and salt and fluid retention.”
Check it at the source: the aspirin, butalbital, caffeine and codeine FDA label on DailyMed (effective May 27, 2026, Bryant Ranch Prepack); the metoprolol FDA label on DailyMed (effective March 3, 2026, Melinta Therapeutics, LLC).
What does the aspirin, butalbital, caffeine and codeine label say about metoprolol?
Aspirin, butalbital, caffeine and codeine label, drug interactionsBeta Blockers Clinical Impact: The hypotensive effects of beta blockers may be diminished by the concomitant administration of aspirin due to inhibition of renal prostaglandins, leading to decreased renal blood flow, and salt and fluid retention. Intervention: Use caution if using concomitantly. Evaluate the blood pressure and renal function of patients. Examples: Metoprolol, propranolol
Source: FDA drug label (BUTALBITAL, ASPIRIN, CAFFEINE AND CODEINE PHOSPHATE), ANDA075231 (Lgm Pharma), as published by Bryant Ranch Prepack, effective May 27, 2026 (SPL set 95a33c9b-79a6-47c7-8433-fc217950b88f), via openFDA; the full label on DailyMed
What does the metoprolol label say about aspirin, butalbital, caffeine and codeine?
Metoprolol's label (effective March 3, 2026) and its 3 other brand-application labels do not name aspirin, butalbital, caffeine and codeine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TOPROL XL), Melinta Therapeutics, LLC, effective March 3, 2026 (SPL set 496ddfaa-7c9c-4888-b747-a210249b367a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin, butalbital, caffeine and codeine | Metoprolol | |
|---|---|---|
| Labeled for | Pain | High blood pressure, Angina, Heart failure, Heart attack and coronary artery disease |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.00 per capsule Ascomp with codeine capsule | $0.085 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once