What the FDA labels say about taking them together

Aspirin, butalbital, caffeine and codeine and heparin

Aspirin, butalbital, caffeine and codeine's FDA label of May 27, 2026 names heparin in its drug interactions section; heparin's label does not name aspirin, butalbital, caffeine and codeine itself but warns about its class (Barbiturates, Stimulants, NSAIDs (nonsteroidal anti-inflammatory drugs), Opioids (opioid agonists), platelet aggregation inhibitors). The aspirin, butalbital, caffeine and codeine label: “Aspirin may enhance the effects of anticoagulants. Concurrent use may increase the risk of bleeding. Aspirin can also displace warfarin from protein binding sites, leading to prolongation of both the prothrombin time …”

Check it at the source: the aspirin, butalbital, caffeine and codeine FDA label on DailyMed (effective May 27, 2026, Bryant Ranch Prepack); the heparin FDA label on DailyMed (effective November 28, 2025, Fresenius Kabi USA, LLC).

What does the aspirin, butalbital, caffeine and codeine label say about heparin?

Aspirin, butalbital, caffeine and codeine label, drug interactions
Clinical Impact: Aspirin may enhance the effects of anticoagulants. Concurrent use may increase the risk of bleeding. Aspirin can also displace warfarin from protein binding sites, leading to prolongation of both the prothrombin time and the bleeding time. Intervention: Evaluate patients for signs of bleeding. Warfarin, heparin, enoxaparin, clopidogrel, prasugrel, rivaroxaban, apixaban Uricosuric Agents

Source: FDA drug label (BUTALBITAL, ASPIRIN, CAFFEINE AND CODEINE PHOSPHATE), ANDA075231 (Lgm Pharma), as published by Bryant Ranch Prepack, effective May 27, 2026 (SPL set 95a33c9b-79a6-47c7-8433-fc217950b88f), via openFDA; the full label on DailyMed

What does the heparin label say about aspirin, butalbital, caffeine and codeine?

Heparin's label does not name aspirin, butalbital, caffeine and codeine itself; it warns about its class (Barbiturates, Stimulants, NSAIDs (nonsteroidal anti-inflammatory drugs), Opioids (opioid agonists), platelet aggregation inhibitors):

Heparin label, drug interactions
Drugs such as NSAIDS (including salicylic acid, ibuprofen, indomethacin, and celecoxib), dextran, phenylbutazone, thienopyridines, dipyridamole, hydroxychloroquine, glycoprotein IIb/IIIa antagonists (including abciximab, eptifibatide, and tirofiban), and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium.

Heparin label, drug interactions
To reduce the risk of bleeding, a reduction in the dose of antiplatelet agent or heparin is recommended.

Source: FDA drug label (Heparin Sodium), Fresenius Kabi USA, LLC, effective November 28, 2025 (SPL set d55b4a63-0c04-4874-b74f-9e9b9e8b008c), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

4Aspirin, butalbital, caffeine and codeine generic labelers

18Heparin generic labelers

	Aspirin, butalbital, caffeine and codeine	Heparin
Labeled for	Pain	Blood clots (DVT and PE), Atrial fibrillation
Boxed warning	Yes	No
Pharmacy cost (NADAC)	$1.00 per capsule Ascomp with codeine capsule	$1.18 per mL 5,000 unit/mL vial
Shortage now	No current entry	In shortage

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?

Aspirin, butalbital, caffeine and codeine: the full record
Heparin: the full record
Check more medicines together: up to five at once