What the FDA labels say about taking them together
Aspirin, butalbital, caffeine and codeine and cisplatin
Aspirin, butalbital, caffeine and codeine's FDA label of May 27, 2026 names cisplatin in its drug interactions section; the cisplatin label PlainMeds reads does not name aspirin, butalbital, caffeine and codeine. The aspirin, butalbital, caffeine and codeine label: “Concomitant use with aspirin may lead to additive nephrotoxicity due to the inhibition of renal prostaglandins by aspirin. Also, the plasma concentration of aspirin is increased by conditions that reduce the glomerular …”
Check it at the source: the aspirin, butalbital, caffeine and codeine FDA label on DailyMed (effective May 27, 2026, Bryant Ranch Prepack); the cisplatin FDA label on DailyMed (effective September 16, 2021, WG Critical Care, LLC).
What does the aspirin, butalbital, caffeine and codeine label say about cisplatin?
Aspirin, butalbital, caffeine and codeine label, drug interactionsClinical Impact: Concomitant use with aspirin may lead to additive nephrotoxicity due to the inhibition of renal prostaglandins by aspirin. Also, the plasma concentration of aspirin is increased by conditions that reduce the glomerular filtration rate or tubular secretion. Intervention: Use ASCOMP with Codeine with caution if used concomitantly with nephrotoxic agents. Frequently evaluate the renal function of patients. Aminoglycosides, amphotericin B, systemic bacitracin, cisplatin, cyclosporine, foscarnet, or parenteral vancomycin Angiotensin Converting Enzyme (ACE) …
Source: FDA drug label (BUTALBITAL, ASPIRIN, CAFFEINE AND CODEINE PHOSPHATE), ANDA075231 (Lgm Pharma), as published by Bryant Ranch Prepack, effective May 27, 2026 (SPL set 95a33c9b-79a6-47c7-8433-fc217950b88f), via openFDA; the full label on DailyMed
What does the cisplatin label say about aspirin, butalbital, caffeine and codeine?
Cisplatin's label (effective September 16, 2021) does not name aspirin, butalbital, caffeine and codeine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (CISplatin), NDA018057 (Hq Spclt Pharma), as published by WG Critical Care, LLC, effective September 16, 2021 (SPL set 2bf8d2fb-80c8-401d-8e9b-d58463f5e954), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin, butalbital, caffeine and codeine | Cisplatin | |
|---|---|---|
| Labeled for | Pain | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.00 per capsule Ascomp with codeine capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once