What the FDA labels say about taking them together
Aspirin, butalbital, caffeine and codeine and captopril
Aspirin, butalbital, caffeine and codeine's FDA label of May 27, 2026 names captopril in its drug interactions section; captopril's label does not name aspirin, butalbital, caffeine and codeine itself but warns about its class (Barbiturates, Stimulants, NSAIDs (nonsteroidal anti-inflammatory drugs), Opioids (opioid agonists), platelet aggregation inhibitors).
Check it at the source: the aspirin, butalbital, caffeine and codeine FDA label on DailyMed (effective May 27, 2026, Bryant Ranch Prepack); the captopril FDA label on DailyMed (effective February 6, 2026, AiPing Pharmaceutical, Inc.).
What does the aspirin, butalbital, caffeine and codeine label say about captopril?
Aspirin, butalbital, caffeine and codeine label, drug interactionsAngiotensin Converting Enzyme (ACE) Inhibitors Clinical Impact: The hyponatremic and hypotensive effects of ACE inhibitors may be diminished by the concomitant administration of aspirin due to its indirect effect on the renin-angiotensin conversion pathway. Intervention: Use caution if using concomitantly. Evaluate the blood pressure and renal function of patients. Examples: Ramipril, captopril
Source: FDA drug label (BUTALBITAL, ASPIRIN, CAFFEINE AND CODEINE PHOSPHATE), ANDA075231 (Lgm Pharma), as published by Bryant Ranch Prepack, effective May 27, 2026 (SPL set 95a33c9b-79a6-47c7-8433-fc217950b88f), via openFDA; the full label on DailyMed
What does the captopril label say about aspirin, butalbital, caffeine and codeine?
Captopril's label does not name aspirin, butalbital, caffeine and codeine itself; it warns about its class (Barbiturates, Stimulants, NSAIDs (nonsteroidal anti-inflammatory drugs), Opioids (opioid agonists), platelet aggregation inhibitors):
Captopril label, drug interactionsAvoid use of aliskiren with captopril tablets in patients with renal impairment (GFR <60 ml/min). Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase – 2 Inhibitors (COX-2 Inhibitors):
Captopril label, drug interactionsMonitor renal function periodically in patients receiving captopril and NSAID therapy.
Source: FDA drug label (Captopril), AiPing Pharmaceutical, Inc., effective February 6, 2026 (SPL set 3b789f16-b291-4012-be39-af3beec3ff9a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin, butalbital, caffeine and codeine | Captopril | |
|---|---|---|
| Labeled for | Pain | High blood pressure, Heart failure, Chronic kidney disease |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.00 per capsule Ascomp with codeine capsule | $0.228 per tablet 12.5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once