What the FDA labels say about taking them together
Aspirin and zafirlukast
Zafirlukast's FDA label of December 1, 2023 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name zafirlukast. The zafirlukast label: “Coadministration of zafirlukast (40 mg/day) with aspirin (650 mg four times daily) resulted in mean increased plasma levels of zafirlukast by approximately 45%.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the zafirlukast FDA label on DailyMed (effective December 1, 2023, Aurobindo Pharma Limited).
What does the aspirin label say about zafirlukast?
Aspirin's label (effective September 9, 2025) does not name zafirlukast in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the zafirlukast label say about aspirin?
Zafirlukast label, drug interactionsCoadministration of zafirlukast (40 mg/day) with aspirin (650 mg four times daily) resulted in mean increased plasma levels of zafirlukast by approximately 45%.
Source: FDA drug label (Zafirlukast), Aurobindo Pharma Limited, effective December 1, 2023 (SPL set 8bdb47c5-9d19-4d59-94c8-62c117525e7f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Zafirlukast | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Asthma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.623 per tablet 20 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once