What the FDA labels say about taking them together
Aspirin and vilazodone
Vilazodone's FDA label of May 22, 2024 names aspirin in its warnings and precautions section; the aspirin label PlainMeds reads does not name vilazodone. The vilazodone label: “Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk. Activation of Mania/Hypomania:”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the vilazodone FDA label on DailyMed (effective May 22, 2024, Teva Pharmaceuticals, Inc.).
What does the aspirin label say about vilazodone?
Aspirin's label (effective September 9, 2025) does not name vilazodone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the vilazodone label say about aspirin?
Vilazodone label, warnings and precautionsConcomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk. ( 5.3 ) Activation of Mania/Hypomania:
Source: FDA drug label (Vilazodone Hydrochloride), Teva Pharmaceuticals, Inc., effective May 22, 2024 (SPL set 3a4745a0-de23-4b40-923e-0d7dfe6b8634), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Vilazodone | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.732 per tablet 10 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once