What the FDA labels say about taking them together
Aspirin and tolmetin
Tolmetin's FDA label of July 20, 2026 names aspirin in its contraindications section; aspirin's label does not name tolmetin itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The tolmetin label: “There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the tolmetin FDA label on DailyMed (effective July 20, 2026, Chartwell RX, LLC).
What does the aspirin label say about tolmetin?
Aspirin's label does not name tolmetin itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Aspirin label, warningsThis product contains an NSAID, which may cause severe stomach bleeding.
Aspirin label, warningsThe chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcohol drinks every day while using this product take more or for a longer time than directed
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the tolmetin label say about aspirin?
Tolmetin label, contraindicationsTolmetin should not be given to patients who have experienced asthma, urticaria or allergic-type reactions after taking aspirin or other NSAIDs.
Tolmetin label, warningsThere is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use.
Source: FDA drug label (Tolmetin Sodium), Chartwell RX, LLC, effective July 20, 2026 (SPL set 66fa5e73-477c-4bbc-b7d3-f4a69aad4460), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Tolmetin | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Osteoarthritis, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once