What the FDA labels say about taking them together
Aspirin and prednisolone
Prednisolone's FDA label of June 25, 2026 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name prednisolone. The prednisolone label: “Concomitant use of aspirin and corticosteroids increases the risk of gastrointestinal side effects.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the prednisolone FDA label on DailyMed (effective June 25, 2026, PAI Holdings, LLC dba PAI Pharma).
What does the aspirin label say about prednisolone?
Aspirin's label (effective September 9, 2025) does not name prednisolone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the prednisolone label say about aspirin?
Prednisolone label, drug interactionsConcomitant use of aspirin (or other non-steroidal anti-inflammatory agents) and corticosteroids increases the risk of gastrointestinal side effects.
Source: FDA drug label (Orapred Odt, NDA021959), Advanz Pharma (US) Corp., effective June 3, 2025 (SPL set 1e379543-c4cf-4e72-953b-db15b7f0c2a1), via openFDA
Source: FDA drug label (PrednisoLONE Sodium Phosphate), PAI Holdings, LLC dba PAI Pharma, effective June 25, 2026 (SPL set d1f937e7-fed5-4079-bd52-5d930b34ae9f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Prednisolone | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Anemia, Leukemia, lymphoma and myeloma, Multiple sclerosis, Osteoarthritis, Asthma, Allergies, Herpes and shingles, Crohn's disease and ulcerative colitis, Eczema (atopic dermatitis), Organ transplant rejection |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $4.72 per mL 1% eye drop |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once