What the FDA labels say about taking them together
Aspirin and niacin
Niacin's FDA label of February 14, 2023 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name niacin. The niacin label: “Concomitant aspirin may decrease the metabolic clearance of nicotinic acid.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the niacin FDA label on DailyMed (effective February 14, 2023, Aurobindo Pharma Limited).
What does the aspirin label say about niacin?
Aspirin's label (effective September 9, 2025) does not name niacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the niacin label say about aspirin?
Niacin label, drug interactionsConcomitant aspirin may decrease the metabolic clearance of nicotinic acid.
Source: FDA drug label (Niacin), Aurobindo Pharma Limited, effective February 14, 2023 (SPL set 43233a21-3f90-4c69-bbeb-f50d5f2d35ae), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Niacin | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | High cholesterol, Heart attack and coronary artery disease, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.193 per tablet 500 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once