What the FDA labels say about taking them together
Aspirin and milnacipran
Milnacipran's FDA label of September 10, 2025 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name milnacipran. The milnacipran label: “Drugs that Interfere with Hemostasis Concomitant use of SAVELLA with an antiplatelet or anticoagulant drug may potentiate the risk of bleeding.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the milnacipran FDA label on DailyMed (effective September 10, 2025, Allergan, Inc.).
What does the aspirin label say about milnacipran?
Aspirin's label (effective September 9, 2025) does not name milnacipran in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the milnacipran label say about aspirin?
Milnacipran label, drug interactionsDrugs that Interfere with Hemostasis Concomitant use of SAVELLA with an antiplatelet or anticoagulant drug (e.g., NSAIDs, aspirin, and warfarin) may potentiate the risk of bleeding.
Milnacipran label, warnings and precautionsCaution patients about the risk of bleeding associated with the concomitant use of SAVELLA and NSAIDs, aspirin, or other drugs that affect coagulation ( 5.9 ).
Source: FDA drug label (Savella), NDA022256 (Abbvie), as published by Allergan, Inc., effective September 10, 2025 (SPL set 16a4a314-f97e-4e91-95e9-576a3773d284), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Milnacipran | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Nerve pain and fibromyalgia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $2.82 per tablet 100 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once