What the FDA labels say about taking them together
Aspirin and methazolamide
Methazolamide's FDA label of October 23, 2025 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name methazolamide. The methazolamide label: “Caution is advised for patients receiving high-dose aspirin and methazolamide concomitantly, as anorexia, tachypnea, lethargy, coma and death have been reported with concomitant use of high-dose aspirin and carbonic …”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the methazolamide FDA label on DailyMed (effective October 23, 2025, Bausch & Lomb Incorporated).
What does the aspirin label say about methazolamide?
Aspirin's label (effective September 9, 2025) does not name methazolamide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the methazolamide label say about aspirin?
Methazolamide label, drug interactionsCaution is advised for patients receiving high-dose aspirin and methazolamide concomitantly, as anorexia, tachypnea, lethargy, coma and death have been reported with concomitant use of high-dose aspirin and carbonic anhydrase inhibitors (see WARNINGS ).
Source: FDA drug label (Methazolamide), Bausch & Lomb Incorporated, effective October 23, 2025 (SPL set 0c0ba5c7-c53e-4e29-a7ff-48fddc5a9258), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Methazolamide | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.627 per tablet 25 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once