What the FDA labels say about taking them together
Aspirin and melphalan
Melphalan's FDA label (Hepzato Kit) of June 9, 2026 names aspirin in its warnings and precautions section; the aspirin label PlainMeds reads does not name melphalan.
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the melphalan FDA label on DailyMed (effective July 7, 2026, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.).
What does the aspirin label say about melphalan?
Aspirin's label (effective September 9, 2025) does not name melphalan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the melphalan label say about aspirin?
Hepzato Kit label (Delcath Systems, Inc., June 9, 2026), warnings and precautionsDiscontinue drugs affecting platelet function such as aspirin, non-steroidal anti-inflammatory drugs, or other anti-platelet drugs one week before the procedure.
Source: FDA drug label (Hepzato Kit, NDA201848), Delcath Systems, Inc., effective June 9, 2026 (SPL set 4f83c8f7-4cc0-4219-88d5-7cfddce91198), via openFDA
Source: FDA drug label (Melphalan hydrochloride), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective July 7, 2026 (SPL set 2c18beeb-7bd4-4591-94cb-9d7156c1b8e0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Melphalan | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Leukemia, lymphoma and myeloma |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | n/a |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once