What the FDA labels say about taking them together
Aspirin and meclofenamate
Meclofenamate's FDA label of April 15, 2026 names aspirin in its contraindications section; the aspirin label PlainMeds reads does not name meclofenamate. The meclofenamate label: “Aspirin When meclofenamate sodium in administered with aspirin, its protein binding is reduced, although the clearance of free meclofenamate sodium is not altered.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the meclofenamate FDA label on DailyMed (effective April 15, 2026, Mylan Pharmaceuticals Inc.).
What does the aspirin label say about meclofenamate?
Aspirin's label (effective September 9, 2025) does not name meclofenamate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the meclofenamate label say about aspirin?
Meclofenamate label, contraindicationsMeclofenamate sodium capsules should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
Meclofenamate label, drug interactionsAspirin When meclofenamate sodium in administered with aspirin, its protein binding is reduced, although the clearance of free meclofenamate sodium is not altered.
Meclofenamate label, warningsThere is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use.
Source: FDA drug label (Meclofenamate Sodium), Mylan Pharmaceuticals Inc., effective April 15, 2026 (SPL set 96f19af4-de8f-4fd7-90d8-55fe6ebdd81d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Meclofenamate | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Fever, Pain, Rheumatoid arthritis, Osteoarthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once