What the FDA labels say about taking them together
Aspirin and ibuprofen
Ibuprofen's FDA label of January 1, 2026 names aspirin in its contraindications (prescription label) section; aspirin's label does not name ibuprofen itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The ibuprofen label: “Ibuprofen and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of ibuprofen and anticoagulants have an increased risk of serious bleeding compared to the use of either drug …”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the ibuprofen FDA label on DailyMed (effective January 1, 2026, Savings Distributors LLC).
What does the aspirin label say about ibuprofen?
Aspirin's label does not name ibuprofen itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Aspirin label, warningsThis product contains an NSAID, which may cause severe stomach bleeding.
Aspirin label, warningsThe chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcohol drinks every day while using this product take more or for a longer time than directed
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the ibuprofen label say about aspirin?
Ibuprofen label, contraindications (prescription label)Ibuprofen tablets should not be given to patients who have experienced asthma, urticarial, or allergic-type reactions after taking aspirin or other NSAIDs.
Ibuprofen label, drug interactions (prescription label)The interaction is alleviated if immediate-release low-dose aspirin is dosed at least 2 hours prior to a once daily regimen of ibuprofen; however, this finding cannot be extended to enteric-coated low-dose aspirin [see Clinical Pharmacology /Pharmacodynamics].
Ibuprofen label, warningsWarnings Allergy Alert: Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin.
Caldolor label (Cumberland Pharmaceuticals Inc., January 29, 2026), contraindicationsCONTRAINDICATIONS CALDOLOR is contraindicated in the following patients: Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to ibuprofen or any components of the drug product [ see Warnings and Precautions ( 5.7 , 5.9 ) ] History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
Caldolor label (Cumberland Pharmaceuticals Inc., January 29, 2026), drug interactionsDrugs That Interfere with Hemostasis Clinical Impact: Ibuprofen and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of ibuprofen and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone. Serotonin released by platelets plays an important role in hemostasis. … Intervention: Monitor patients with concomitant use of CALDOLOR with anticoagulants (e.g., warfarin), antiplatelet agents (e.g., aspirin), selective serotonin reuptake inhibitors (SSRIs), and serotonin norepinephrine reuptake inhibitors (SNRIs) for signs of bleeding [ see Warnings and Precautions () ].
Caldolor label (Cumberland Pharmaceuticals Inc., January 29, 2026), warnings and precautionsMonitor patients with preexisting asthma (without aspirin sensitivity).
Source: FDA drug label (Caldolor, NDA022348), Cumberland Pharmaceuticals Inc., effective January 29, 2026 (SPL set 1eaa7790-f1a1-4f51-b10a-cbbaf033f684), via openFDA
Source: FDA drug label (Motrin IB), NDA019012 (Kenvue Brands), as published by Savings Distributors LLC, effective January 1, 2026 (SPL set 56846774-8413-c306-e063-6394a90a2be8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Ibuprofen | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Fever, Osteoarthritis, Rheumatoid arthritis, Pain, Cough and cold |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.0573 per tablet 800 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once