What the FDA labels say about taking them together
Aspirin and divalproex
Divalproex's FDA label of March 31, 2026 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name divalproex. The divalproex label: “… whenever enzyme-inducing or inhibiting drugs are introduced or withdrawn Aspirin, carbapenem antibiotics, estrogen-containing hormonal contraceptives, methotrexate:”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the divalproex FDA label on DailyMed (effective March 31, 2026, AbbVie Inc.).
What does the aspirin label say about divalproex?
Aspirin's label (effective September 9, 2025) does not name divalproex in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the divalproex label say about aspirin?
Divalproex label, drug interactionsTherefore increased monitoring of valproate and concomitant drug concentrations and dosage adjustment are indicated whenever enzyme-inducing or inhibiting drugs are introduced or withdrawn ( 7.1 ) Aspirin, carbapenem antibiotics, estrogen-containing hormonal contraceptives, methotrexate:
Source: FDA drug label (Depakote), AbbVie Inc., effective March 31, 2026 (SPL set 08a65cf4-7749-4ceb-6895-8f4805e2b01f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Divalproex | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Bipolar disorder, Migraine, Seizures and epilepsy |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.194 per tablet 500 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once