What the FDA labels say about taking them together
Aspirin and dimethyl fumarate
Dimethyl fumarate's FDA label of July 29, 2025 names aspirin in its warnings and precautions section; the aspirin label PlainMeds reads does not name dimethyl fumarate. The dimethyl fumarate label: “Alternatively, administration of non-enteric coated aspirin (up to a dose of 325 mg) 30 minutes prior to TECFIDERA dosing may reduce the incidence or severity of flushing.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the dimethyl fumarate FDA label on DailyMed (effective July 29, 2025, Macleods Pharmaceuticals Limited).
What does the aspirin label say about dimethyl fumarate?
Aspirin's label (effective September 9, 2025) does not name dimethyl fumarate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the dimethyl fumarate label say about aspirin?
Dimethyl fumarate label, warnings and precautionsAlternatively, administration of non-enteric coated aspirin (up to a dose of 325 mg) 30 minutes prior to dimethyl fumarate delayed-release capsules dosing may reduce the incidence or severity of flushing [see Dosing and Administration ( 2.1 ) and Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Tecfidera, NDA204063), Biogen Inc., effective June 4, 2025 (SPL set 665d7e74-036c-5f68-5b67-ab84b9b49151), via openFDA
Source: FDA drug label (Dimethyl Fumarate), Macleods Pharmaceuticals Limited, effective July 29, 2025 (SPL set f8ada3e3-55c0-43e3-95b9-c6d11ffc42dd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Dimethyl fumarate | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Multiple sclerosis |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.467 per capsule 240 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once