What the FDA labels say about taking them together
Aspirin and diclofenac
Diclofenac's FDA label of February 11, 2025 names aspirin in its contraindications (prescription label) section; aspirin's label does not name diclofenac itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The diclofenac label: “Diclofenac and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of diclofenac and anticoagulants have an increased risk of serious bleeding compared to the use of either drug …”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the diclofenac FDA label on DailyMed (effective February 11, 2025, Haleon US Holdings LLC).
What does the aspirin label say about diclofenac?
Aspirin's label does not name diclofenac itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Aspirin label, warningsThis product contains an NSAID, which may cause severe stomach bleeding.
Aspirin label, warningsThe chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcohol drinks every day while using this product take more or for a longer time than directed
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the diclofenac label say about aspirin?
Diclofenac label, contraindications (prescription label)Diclofenac sodium topical gel should not be administered in patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
Diclofenac label, drug interactions (prescription label)Concomitant administration of diclofenac and aspirin is not generally recommended because of the potential of increased adverse effects including increased GI bleeding.
Diclofenac label, warnings and precautions (prescription label)Anaphylactoid reactions may occur in patients with the aspirin triad or in patients without prior exposure to diclofenac sodium topical gel and should be discontinued immediately if an anaphylactoid reaction occurs.
Diclofenac label, warningsWarnings For external use only Allergy alert: Diclofenac may cause a severe allergic reaction, especially in people allergic to aspirin.
Licart label (IBSA Pharma Inc., April 2, 2026), contraindicationsHistory of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
Licart label (IBSA Pharma Inc., April 2, 2026), drug interactionsDrugs That Interfere with Hemostasis Clinical Impact: Diclofenac and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of diclofenac and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone. Serotonin release by platelets plays an important role in hemostasis. … Intervention: Monitor patients with concomitant use of LICART with anticoagulants (e.g., warfarin), antiplatelet agents (e.g., aspirin), selective serotonin reuptake inhibitors (SSRIs), and serotonin norepinephrine reuptake inhibitors (SNRIs) for signs of bleeding [see ].
Source: FDA drug label (Voltaren Arthritis Pain), Haleon US Holdings LLC, effective February 11, 2025 (SPL set 30a94282-0892-442a-aa10-6525cbd4fe88), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Diclofenac | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Pain, Osteoarthritis, Rheumatoid arthritis, Migraine |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.0619 per tablet 75 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once