What the FDA labels say about taking them together
Aspirin and dichlorphenamide
Dichlorphenamide's FDA label of March 4, 2026 names aspirin in its contraindications section; the aspirin label PlainMeds reads does not name dichlorphenamide. The dichlorphenamide label: “The concomitant use of KEVEYIS and high-dose aspirin is contraindicated.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the dichlorphenamide FDA label on DailyMed (effective March 4, 2026, Xeris Pharmaceuticals, Inc.).
What does the aspirin label say about dichlorphenamide?
Aspirin's label (effective September 9, 2025) does not name dichlorphenamide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the dichlorphenamide label say about aspirin?
Dichlorphenamide label, contraindicationsCONTRAINDICATIONS KEVEYIS is contraindicated in the following circumstances: Hypersensitivity to dichlorphenamide or other sulfonamides [see Warnings and Precautions (5.1) ] Concomitant use of KEVEYIS and high dose aspirin [see Warnings and Precautions (5.2) and Drug Interactions (7.1) ] Severe pulmonary disease, limiting compensation to metabolic acidosis caused by KEVEYIS [see Warnings and Precautions (5.4) ] Hepatic insufficiency:
Dichlorphenamide label, drug interactionsThe concomitant use of KEVEYIS and high-dose aspirin is contraindicated.
Dichlorphenamide label, warnings and precautionsUse of Aspirin or Other Salicylates Carbonic anhydrase inhibitors, including KEVEYIS, can cause metabolic acidosis [see Warnings and Precautions (5.4) ], which can increase the risk of salicylate toxicity.
Source: FDA drug label (Keveyis), Xeris Pharmaceuticals, Inc., effective March 4, 2026 (SPL set d30a87b9-90fb-35b2-e053-2995a90aea2c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Dichlorphenamide | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once