What the FDA labels say about taking them together
Aspirin and collagenase clostridium histolyticum
Collagenase clostridium histolyticum's FDA label (Xiaflex) of April 22, 2026 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name collagenase clostridium histolyticum. The collagenase clostridium histolyticum label: “DRUG INTERACTIONS Anticoagulant drugs: XIAFLEX should be used with caution in patients receiving concomitant anticoagulants.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the collagenase clostridium histolyticum FDA label on DailyMed (effective May 17, 2019).
What does the aspirin label say about collagenase clostridium histolyticum?
Aspirin's label (effective September 9, 2025) does not name collagenase clostridium histolyticum in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the collagenase clostridium histolyticum label say about aspirin?
Xiaflex label (Endo USA, Inc., April 22, 2026), drug interactionsDRUG INTERACTIONS Anticoagulant drugs: XIAFLEX should be used with caution in patients receiving concomitant anticoagulants (except for low-dose aspirin) [see Warnings and Precautions (5.5)].
Xiaflex label (Endo USA, Inc., April 22, 2026), warnings and precautionsIn addition, it is recommended to avoid use of XIAFLEX in patients with coagulation disorders, including patients receiving concomitant anticoagulants (except for low-dose aspirin).
Source: FDA drug label (Xiaflex, BLA125338), Endo USA, Inc., effective April 22, 2026 (SPL set 805cecd0-fd1f-11dd-87af-0800200c9a66), via openFDA
Source: FDA drug label (COLLAGENASE SANTYL), SMITH & NEPHEW, INC, effective May 17, 2019 (SPL set 6b6fbfc6-98fa-46aa-88ef-ab00fbb08ffd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Collagenase clostridium histolyticum | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once