What the FDA labels say about taking them together
Aspirin and bismuth subsalicylate
Bismuth subsalicylate's FDA label of October 3, 2023 names aspirin in its warnings section; the aspirin label PlainMeds reads does not name bismuth subsalicylate. The bismuth subsalicylate label: “Do not take if you are allergic to salicylates (including aspirin) taking other salicylate products Do not use if you have an ulcer a bleeding problem bloody or black stool Ask a doctor before use if you have fever …”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the bismuth subsalicylate FDA label on DailyMed (effective October 3, 2023).
What does the aspirin label say about bismuth subsalicylate?
Aspirin's label (effective September 9, 2025) does not name bismuth subsalicylate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the bismuth subsalicylate label say about aspirin?
Bismuth subsalicylate label, warningsDo not take if you are allergic to salicylates (including aspirin) taking other salicylate products Do not use if you have an ulcer a bleeding problem bloody or black stool Ask a doctor before use if you have fever mucus in the stool Ask a doctor or pharmacist before use if you are taking any drug for anticoagulation (thinning the blood) diabetes gout arthritis When using this product a temporary, but harmless, darkening of the stool and/or tongue may occur Stop use and ask a doctor if symptoms get worse or last more than 2 days ringing in the ears or loss of hearing occurs diarrhea lasts more than 2 days If pregnant or breast feeding, ask a health professional before use.
Source: FDA drug label (Pepto-Bismol Chewable, TRAVEL BASIX), Lil' Drug Store Products, Inc., effective October 3, 2023 (SPL set dd2f2205-34d1-4960-bf37-bb8d534cd0e1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Bismuth subsalicylate | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Diarrhea, Acid reflux and ulcers, Nausea and vomiting |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.0817 per tablet 262 mg tablet chewable |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once