What the FDA labels say about taking them together
Asparaginase and liothyronine
Liothyronine's FDA label of June 4, 2026 names asparaginase in its drug interactions section; the asparaginase label PlainMeds reads does not name liothyronine. The liothyronine label: “Androgens/Anabolic Steroids Asparaginase Glucocorticoids Slow-Release Nicotinic Acid These drugs may decrease serum TBG concentration.”
Check it at the source: the asparaginase FDA label on DailyMed (effective July 1, 2025); the liothyronine FDA label on DailyMed (effective June 4, 2026, Mylan Pharmaceuticals Inc.).
What does the asparaginase label say about liothyronine?
Asparaginase's label (effective July 1, 2025) does not name liothyronine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Rylaze), Jazz Pharmaceuticals, Inc., effective July 1, 2025 (SPL set 857e53aa-1098-4dad-b654-0276cdd43e03), via openFDA; the full label on DailyMed
What does the liothyronine label say about asparaginase?
Liothyronine label, drug interactionsAndrogens/Anabolic Steroids Asparaginase Glucocorticoids Slow-Release Nicotinic Acid These drugs may decrease serum TBG concentration.
Source: FDA drug label (Liothyronine Sodium), NDA010379 (King Pharms), as published by Mylan Pharmaceuticals Inc., effective June 4, 2026 (SPL set 115a84c2-0126-4dd7-816e-1873875f1e49), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Asparaginase | Liothyronine | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Hypothyroidism |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.294 per tablet 25 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once