What the FDA labels say about taking them together
Asparaginase and epinephrine
Asparaginase's FDA label of July 1, 2025 names epinephrine in its warnings and precautions section; the epinephrine labels PlainMeds reads (4) do not name asparaginase. The asparaginase label: “Because of the risk of serious allergic reactions, administer RYLAZE in a setting with resuscitation equipment and other agents necessary to treat anaphylaxis.”
Check it at the source: the asparaginase FDA label on DailyMed (effective July 1, 2025); the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions).
What does the asparaginase label say about epinephrine?
Asparaginase label, warnings and precautionsBecause of the risk of serious allergic reactions (e.g., life-threatening anaphylaxis), administer RYLAZE in a setting with resuscitation equipment and other agents necessary to treat anaphylaxis (e.g., epinephrine, oxygen, intravenous steroids, antihistamines) [see Dosage and Administration ( 2.3 )].
Source: FDA drug label (Rylaze), Jazz Pharmaceuticals, Inc., effective July 1, 2025 (SPL set 857e53aa-1098-4dad-b654-0276cdd43e03), via openFDA; the full label on DailyMed
What does the epinephrine label say about asparaginase?
Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name asparaginase in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Asparaginase | Epinephrine | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Asthma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $123.51 per unit 0.15 mg auto-injct |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once